2023/02/15 | Events | In-vitro & Organs-on-Chip
First ARTORG Seminar 2023 hosted by the Organs-on-Chip Technologies lab with Arunima Sengupta.
Abstract:
Prolonged exposure to environmental inhalants is a major trigger for the development and progression of severe respiratory conditions like asthma, COPD and fibrosis. Animal inhalation studies present species-specific variations and makes it difficult to draw conclusions in human. Hence, there is an urgent need to develop “new approach methodologies” which are able to reproduce breathing lung dynamics and inhalation mechanism.
Here, we present a mechanistic approach using a novel in vitro inhalation tool integrated with a breathing lung-on-chip (AlveoliX) technology. To mimic in vivo relevant aerosol exposures with the platform we have performed three proof-of-concept models, (a) using relevant environmental nanoparticles, (b) toxic inhaled chemicals and (c) anti-inflammatory inhaled drugs. Our results suggest that this system will prove to be a valuable pre-clinical tool to study inhalation toxicity, drug safety and efficacy.
Hybrid event: Join here for Zoom.
