2023/03/15 | Events | Biomechanics
Second ARTORG Seminar 2023 hosted by the Musculoskeletal Biomechanics lab with Xiao-Hua Qin.
Dr. Xiao-Hua Qin is a Senior Researcher and Lecturer in the Institute for Biomechanics (IfB) at ETH Zurich. He is leading a multidisciplinary research team ‘‘Micro-Tissue Engineering and Biomaterials’’ in the Bone Biomechanics laboratory. He received a Ph.D. degree (2014) with distinction in Polymer Chemistry at the Vienna University of Technology. After 2 years training at the Ludwig Boltzmann Institute for Clinical Traumatology, he relocated to EMPA St Gallen as a Marie-Curie Postdoc Fellow where he explored new applications of photoresponsive hydrogels in organoid engineering and soft robotics.
Dr. Qin is the recipient of Swiss National Science Foundation Spark Award (2019), ETH Zurich Career Seed Award (2018), Student Award of the Swiss Society for Biomaterials (2013) and several other academic prizes. Very recently, he obtained a 4-year SNSF National Research Programme (NRP) 79 grant to develop a human organoid-on-chip technique to study pathomechanisms of rare bone disease for replacing animal experiments. His research interests include molecularly engineered biomaterials (hydrogels), 3D bioprinting, cell-matrix interactions, organoid technology, and precision tissue engineering.
Recent technological advances have witnessed the development of various 3D in vitro tissue models for disease modeling and drug testing without the need for animal experimentation. Despite important progress, in vitro generation of mm-scale human musculoskeletal tissues that faithfully mimic the structural and functional complexity of their in vivo counterparts remains a substantial challenge. This is largely due to the lack of advanced cell culture techniques that allow exquisite control of cell-cell and cell-material interactions in a 3D microenvironment. In this seminar, I would present our efforts in developing advanced photoresponsive hydrogels and light-assisted 3D bioprinting techniques to create functional bone tissue models across length scales in the laboratory. Specifically, I will highlight these examples: 1) using synthetic cell-responsive photo-clickable hydrogels for 3D culture of primary bone cells to mimic early stage of bone formation; 2) combining medical imaging with tomographic volumetric bioprinting to fabricate perfusable cell-laden hydrogel constructs within 5-15 seconds; and 3) using photocleavable hydrogels for image-guided two-photon biofabrication of 3D cellular networks mimicking the complex bone microarchitecture in a petri dish.
Advanced hydrogels and microtechnologies are interfaced to spatiotemporally control cell-material interactions for laser-guided tissue morphogenesis in a 3D culture. The picture illustrates a laser-printed 3D cellular network to model human bone diseases such as age-related bone loss in a petri dish.
Hybrid event: Join here for Zoom.