ARTORG Center for Biomedical Engineering Research

Higher visual functions: How to improve visual perception in patients with unilateral brain lesion

Project Members: Giuseppe Zito, Urs P Mosimann, René Müri, Tobias Nef
Project Duration: 2012-2015
Project Funding: CTI

Visual perception can be defined as the integration of a series of cognitive processes, including reception, organization, and assimilation of the visual information sent to the cerebral cortex. The visual information is processed in two streams: a ventral stream for object recognition and a dorsal stream for perception of motion. A lesion in the ventral stream can cause impairment in recognition of visually presented objects (visual agnosias), deficit in reading (alexia). Lesions on the dorsal stream can lead to difficulties in perceiving visual motion (akinetopsia). These higher visual functions are of key importance for daily living activities. However, in patients with hemispheric brain lesions, impaired higher visual functions are not always detected in classical neurological examinations. Therefore, we developed a series of new tests to assess higher visual functions (i.e. visual perception of motion, size, shape, and pattern).

In this study, the performances of patients with unilateral brain lesions after stroke or traumatic brain injury, as well as age-matched healthy controls are measured. We plan to use tDCS (transcranial direct current stimulation) to stimulate the impaired region of the brain to enhance the higher visual functions and, therefore, improve the level of performances at the proposed tasks.

Keywords: Visual exploration, visual impairment, higher visual functions, perimeter, brain stimulation


Zito, Giuseppe Angelo; Cazzoli, Dario; Müri, René Martin; Mosimann, Urs Peter; Nef, Tobias(2016). Behavioral Differences in the Upper and Lower Visual Hemifields in Shape and Motion Perception. Frontiers in behavioral neuroscience, 10(128), p. 128. Frontiers Research Foundation10.3389/fnbeh.2016.00128

Zito, Giuseppe Angelo; Senti, Theresa; Cazzoli, Dario; Müri, René Martin; Mosimann, Urs Peter; Nyffeler, Thomas; Nef, Tobias (2015). Cathodal HD-tDCS on the right V5 improves motion perception in humans. Frontiers in behavioral neuroscience, 9(257), p. 257. Frontiers Research Foundation 10.3389/fnbeh.2015.00257

Zito, Giuseppe Angelo; Müri, René Martin; Mosimann, Urs Peter; Nyffeler, Thomas; Nef, Tobias(29 August 2015). Higher Visual Functions in the Upper and Lower Visual Fields: a pilot study in healthy subjects. In: IEEE EMBC 2015. IEEE

Zito, Giuseppe Angelo; Müri, René; Mosimann, Urs Peter; Nyffeler, Thomas; Nef, Tobias (2014).A new method to measure higher visual functions in an immersive environment. Biomedical engineering online, 13, p. 104. BioMed Central 10.1186/1475-925X-13-104