ARTORG Center for Biomedical Engineering Research

Non-invasive brain stimulation and aphasia

Project Members: Rahel Schumacher, Noëmi Eggenberger, Basil Preisig, Thomas Nyffeler, Klemens Gutbrod, René M Müri
Project Duration: 2010-2015
Project Funding: Ernst Göhner Stiftung

Aphasia, an acquired impairment or loss of language functions, is a common consequence after unilateral - usually left hemispheric - stroke. Non-invasive stimulation techniques such as repeated transcranial magnetic stimulation (rTMS) or transcranial direct current stimulation (tDCS) are increasingly used in neuroscience and particularly in neurorehabilitation research. These techniques are able to influence cortical excitability by applying a fast changing magnetic field (rTMS) or (weak) direct current (tDCS) to the brain.

The aim of the project is to study aphasia recovery processes and the possibility to influence them by means of non-invasive brain stimulation techniques. We will evaluate under which circumstances rTMS (in particular an inhibitory theta burst stimulation (TBS) protocol), applied to the nondominant right inferior frontal lobe, can lead to an improvement in language functions in aphasic patients.

Keywords: Aphasia, eye movements, brain stimulation

Publications: 

Schumacher, Rahel; Cazzoli, Dario; Eggenberger, Noëmi; Preisig, Basil; Nef, Tobias; Nyffeler, Thomas; Gutbrod, Klemens; Annoni, Jean-Marie; Müri, René M. (2015). Cue Recognition and Integration - Eye Tracking Evidence of Processing Differences in Sentence Comprehension in Aphasia. PLoS ONE, 10(11), e0142853. Public Library of Science 10.1371/journal.pone.0142853

Preisig, Basil; Eggenberger, Noëmi; Zito, Giuseppe Angelo; Vanbellingen, Tim; Schumacher, Rahel; Hopfner, Simone; Nyffeler, Thomas; Gutbrod, Klemens; Annoni, Jean-Marie; Bohlhalter, Stephan; Müri, René Martin (2015). Perception of co-speech gestures in aphasic patients: A visual exploration study during the observation of dyadic conversations. Cortex, 64, pp. 157-168. Elsevier 10.1016/j.cortex.2014.10.013

Eggenberger, Noëmi; Preisig, Basil; Schumacher, Rahel; Hopfner, Simone; Vanbellingen, Tim; Nyffeler, Thomas; Gutbrod, Klemens; Annoni, JM; Bohlhalter, Stephan; Cazzoli, Dario; Müri, René Martin (2016). Comprehension of co-speech gestures in aphasic patients: An eye movement study. PLoS ONE, 11(1), e0146583. Public Library of Science10.1371/journal.pone.0146583

Preisig, Basil; Eggenberger, Noëmi; Zito, Giuseppe Angelo; Vanbellingen, Tim; Schumacher, Rahel; Hopfner, Simone; Gutbrod, Klemens; Nyffeler, Thomas; Cazzoli, Dario; Annoni, Jean-Marie; Bohlhalter, Stephan; Müri, René Martin (2016). Eye Gaze Behavior at Turn Transition: How Aphasic Patients Process Speakers' Turns during Video Observation. Journal of cognitive neuroscience, 28(10), pp. 1-12. MIT Press Journals 10.1162/jocn_a_00983