Dr. Francesco Clavica

Head Urogenital engineering (UGE)

University of Bern, ARTORG Center for Biomedical Engineering Research, Urogenital Engineering

Phone
+41 31 632 7601
Fax
+41 31 632 7576
E-Mail
francesco.clavica@artorg.unibe.ch
Postal Address
ARTORG Center for Biomedical Engineering Research
Freiburgstrasse 3
CH-3010 Bern
   
2019 - present Group head of Urogenital Engineering Group, ARTORG Center, University of Bern, Switzerland 
2018 - present Senior Reseacher at Center for Artificial muscle (CAM) -  Ecole Polytechnique Fédérale de Lausanne (EPFL)
2018 - present
Senior Researcher at CArdiovascular Engineering Group, ARTORG Center, University of Bern, Switzerland
2011 - 2014 Marie Curie Research fellow at (joint position):
- Department of Urology, Erasmus Medical Center, Rotterdam, The Netherlands    
- Bristol Urological Institute, Southmed hospital, Bristol, United Kingdom      
2007 - 2011 PhD at Brunel Institute for Bioengineering, Brunel University, London, United Kingdom
2007 Apr-Aug Research Assistant at Neurosurgery Department, Cleveland Clinic, Cleveland, USA
2001 - 2006 MSc and BSc in Biomedical Engineering, Politecnico di Milano, Milan, Italy
  • Biomedical fluid dynamics
  • Medical devices for urinary system
  • Medical devices for cardiovascular system
  • Microfluidics
  • Wave analysis
  • Electrophysiology
  • Respiratory system

Journal articles

*Corresponding author

Mantegazza A.*, Clavica F., Obrist D. ‘In vitro investigations of red blood cell phase separation in a complex microchannel network’ Biomicrofluidics (accepted), 2020.

Chakrabarty B., Bijios D., Vahabi B., Clavica F., Kanai A.J., Pickering AE, Fry CH, Drake MJ* 'Modulation of Bladder Wall Micromotions Alters Intravesical Pressure Activity in the Isolated Bladder.' Frontiers in Physiology, 9:193, 2019

Haeberlin A., Schurch K., Niederhauser T., Sweda R., Schneider M,Obrist D., Burkhard F., Clavica F.* ‘Cardiac electrophysiology catheters for electrophysiological assessments of the lower urinary tract—A proof of concept ex vivo study in viable ureters’ Neurourology and Urodynamics, 38(1):87-96, 2019.

Niederhauser T., Gafner E, Cantieni T., Grämiger M., Haeberlin A., Obrist D., Burkhard F., Clavica F.* ‘Detection and quantification of overactive bladder activity in patients: Can we make it better and automatic?’ Neurourology and Urodynamics, 1-9, 2017.

Clavica F.*, Homsy A., Jeandupeux L., Obrist D., ‘Red blood cell phase separation in symmetric and asymmetric microchannel networks: effect of capillary dilation and inflow velocity’ Scientific Reports, Nature publishing group, 6:36763, 2016.

van Asselt E*, Choudhary M, Clavica F, van Mastrigt R. ‘Urethane anesthesia in acute lower urinary tract studies in the male rat.’ Laboratory Animals: 1-7, 2016

Clavica F.*, Choudhary M. S., van Asselt E., van Mastrigt R., “Frequency analysis of urinary bladder pre-voiding activity in normal and overactive rat detrusor.” Neurourology and  Urodynamics, vol. 34, pp. 794-9, 2015.

Choudhary M. S., van Asselt E., van Mastrigt R., Clavica F.*, ‘Neurophysiological modelling of bladder afferent activity in the rat overactive bladder model’, Journal of Physiological Sciences,  65(4):329-38, 2015.

Choudhary M.*, Clavica F., van Mastrigt Ron, van Asselt E.  ‘A novel single compartment in vitro model for electrophysiological research using the Perfluorocarbon FC-770’, Physiological Research, 20;65(2):341-8, 2014.

Clavica F.*,  Zhao X., ElMahdy M., Drake M.J., Zhang X., Carugo D., ‘Beyond the Abstract - A biomimetic artificial model to investigate flow dynamics in the obstructed and stented ureter’, UroToday International Journal 2014.

Clavica F.*, Zhao X., ElMahdy M., Drake M.J., Zhang X., Carugo D., “Investigating the flow dynamics in the obstructed and stented ureter by means of a biomimetic artificial model.” PLOS ONE; 9(2):e87433, 2014.

Clavica F.*, Parker K., *Khir W. A., ‘Wave intensity analysis in air-filled flexible vessels’, Journal of Biomechanics, 26, 48(4):687-94, 2012. 

 

Patents

 

Clavica F., Obrist D., Burkhard F., Schneider M.,  'Urinary pumping device with an implantable activation arrangement';  Euroepan Patent Application EP19/154102.8 priority date: 29.01.2019

Clavica F., Obrist D., Burkhard F., Schneider M.,  'External impedance pump for emptying the bladder'; Swiss Patent Application CH 00096/19priority date: 29.01.2019

Bernard A., Heeb P., Nef C., Obrist D., Clavica F., Frey S., Schwartz R., Hoem J. and Bludau O..  Microfluidic coronary circulatory model. United States Patent Application 4629.003PRV, 2018

 

Peer-reviewed conference papers

*Corresponding author

Clavica F. *, Roth J., Schneider M.P., Civet Y., Burkhard F., Perriard Y., Obrist D. ‘Impedance pumping as a non-invasive treatment for underactive bladder? An ex-vivo proof-of-concept-study in porcine bladders’ Institution of Mechanical Engineers’ conference – Incontinence: the engineering challenge, London, UK, November 2019.

Clavica F. *, Zheng S. Carugo, D., Mosayyebi, A., Waters, S., Civet, Y., Perriard, Y, Obrist D., Burkhard F. ‘Development of a biologically inspired in-vitro platform for long-term assessment of commercial and innovative ureteral stents’ Institution of Mechanical Engineers’ conference – Incontinence: the engineering challenge, London, UK, November 2019.

Mosayyebi A., De Grazia A., Clavica F., Lange D.; Somani B.; Manes C.; Carugo D., ‘Does flow dynamics govern deposition of encrustation in ureteral stents?’ Institution of Mechanical Engineers’ conference – Incontinence: the engineering challenge, London, UK, November 2019.

Mantegazza A.*, Clavica F., Obrist D. ‘Microfluidic investigation of red blood cell phase separation in complex microchannel networks’ 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS), Basel, Switzerland, October 2019

Clavica F. *, Roth J., Schneider M.P., Civet Y., Burkhard F., Perriard Y., Obrist D. ‘Urine-Contactless Device to Empty Bladders: an Ex-Vivo Proof-of-Concept Study in Porcine Bladders’ 49th Annual of Conference of International Continence Society (ICS), Gothenburg, Sweden, September 2019.

Mantegazza A.*, Clavica F., Obrist D. ‘Tubular pinch effect of red blood cells at low Reynolds number in in vitro models of microvascular bifurcations’ 8th World Congress of Biomechanics, Dublin, Ireland.

Mantegazza A.*, Clavica F., Obrist D. ‘In vitro measurements of apparent intrinsic viscosity in function of tube hematocrit and red blood cell velocity’ Blood flow conference, Paris, France, October 2017.

Niederhauser T., Cantieni T., Grämiger M., van Mastrigt R., Burkhard F., Obrist O., Clavica F.*, ‘Towards an automatic detection and quantification of urinary bladder activity in overactive bladder patients’ Annual congress of Swiss, Austrian and German Societies of Biomedical Engineering (BMT conference), Basel, Switzerland, 2016.

Clavica F.*, A. Homsy, L. Jeandupeux, H. Keppner, D. Obrist “Blood cell dynamics in a simple model of microvascular networks” 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS), Gyeongju, South Korea, 2015.

Grundmann A., Clavica F.*, Landolt A., Barrett M., Weber D. Obrist “Measurement of Fluid Pressure in Microchannels” 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS), Gyeongju, South Korea, 2015.

Zolliker D., Niederhauser T., Grämiger M., van Mastrigt R., Burkhard F., Obrist O., Clavica F.*, “Frequency analysis of urinary bladder pre-voiding activity in normal and overactive human detrusor: a pilot study” Proceedings of the 37th Annual International IEEE EMBS Conference, Milan, Italy, 2015.

Carugo D., Zhang X., Drake J. M., Clavica F.*, “Formation and characteristics of laminar vortices in micro-scale environments within an obstructed and stented ureter: a computational study” 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS) San Antonio, USA, 2014.

Clavica F.*, Barrett M., Weiss P., Landolt A, Weber B., Obrist D., “In vivo assessment of hematocrit distribution at bifurcation in cerebral microcirculation” Annual meeting of Swiss Society for Biomed. Engineering, Zurich, Switzerland, 2014.

Choudhary M. S*, van Asselt E., Clavica F., van Mastrigt R. ” Validation of rat overactive bladder model by bladder wall stress estimation”, International Continence Society Conference (ICS), Barcelona, Spain, 2013.

Carugo D., ElMahdy M., Zhao X., Drake M.J., Zhang X., Clavica F.*, “An Artificial Model for Studying Fluid Dynamics in the Obstructed and Stented Ureter”, Proceedings of the 35th Annual International IEEE EMBS Conference, Osaka, Japan, 2013.

Choudhary M. S, van Asselt E., van Mastrigt R., Clavica F.*, “A Novel Single Compartment In Vitro model: Perflurocarbons for Electrophysiological studies of the Rat Urinary Bladder”, Proceedings of the 35th Annual International IEEE EMBS Conference, Osaka, Japan, 2013.

Clavica F.*, Choudhary M. S., van Asselt E., van Mastrigt R., “Can an Algorithm Predict a Voiding Contraction in Unconscious Rats?”, Proceedings of the 35th Annual International IEEE EMBS Conference, Osaka, Japan, 2013.

Bijoś D., Drake M.J.*, Clavica F., Vahabi B., “Identification of anoctamine (Ano1) calcium activated chloride channels in porcine urinary bladder and characterization of their functional role in the bladder using niflumic acid”, International Continence Society Conference (ICS), Bejing, China,  2012.

Choudhary M. S., Clavica F.*, van Asselt E., van Mastrigt R., “Frequency analysis of afferent nerve activity in the rat overactive urinary bladder model”, Proceedings of the 34th Annual International IEEE EMBS Conference, San Diego, USA, 2012

Clavica F.*, Alastruey J., Sherwin S J., Khir A.W., “One-dimensional computational model of an asymmetrical human bronchial tree”, Physiologic Fluid Mechanics Conference, London (UK) (winner of the best poster prize), 2011.

Clavica F.*, Alastruey J., Sherwin S.J., Khir A.W., “One-Dimensional Computational Model of Pulse Wave Propagation in the Human Bronchial Tree”, Proceedings of the 32nd Annual International IEEE EMBS Conference, Buenos Aires, Argentina, 2010.

Clavica F.*, Alastruey J., Sherwin S J., Khir A.W., “One-dimensional Modelling of Wave Propagation in a Model of Human airways”, 17th Congress of the European Society of Biomechanics, Edinburgh, UK, 2010.

Clavica F.*, Alastruey J., Sherwin S.J., Khir A.W., “One-dimensional Modelling of Pulse Wave Propagation in a Model of Human airways”, Proceedings of the 31st Annual International IEEE EMBS Conference, Minneapolis, USA, 2009.