Fluid dynamic investigations in the Urinary system
Urine flows in the urinary system from kidneys, where it is produced, until the 'outlet tube' which is called urethra. Our research focusses on fluid dynamic investigations of urine flow in ureters ('tubes connecting the kidneys to bladder), bladder and urethra in physiological and pathological conditions. Our latest research in this direction aims at improving the performances of existing ureteral stents. Ureteral stents are medical devices that are clinically deployed to restore urine drainage in case of obstructions of the ureteral lumen, which can be either internal (e.g. kidney and ureteral stones) or external (urothelial carcinoma). Despite their wide clinical usage, stents suffer from several complications and side effects.These include irritation, pain, haematuria, and formation of encrusting and bacterial deposits. Encrustation and biofilm formation are widely recognised as primary determinants of stents’ failure.
The UGE group, funded by Swiss National Science Foundation, is building a test platform to help improve the stent’s design for an optimised urine flow which has been found to strongly affect biofilm and encrustation processes in stents.
We are part of the ENIUS COST ACTION - 'European network of multidisciplinary research to improve the urinary stents' . Check ENIUS website for more information about our multidisciplinary and international network.