03.02.2025 | People | Artificial Intelligence

PhD Defense: Matteo Frigelli Develops Predictive Computational Tool for CXL Treatment

On February 3, 2025, Matteo Frigelli successfully defended his PhD thesis titled: “Localized Corneal Stiffening for Refractive Correction: Experiments and Computational Analysis.” In this work, Matteo explored the potential of localized corneal cross-linking as a treatment for refractive correction, utilizing innovative experimental techniques and advanced computational methods.

(Matteo Frigelli)

His findings showed that by localizing the mechanical strengthening induced by cross-linking, desired changes in corneal curvature can be achieved. Building on these insights, Matteo developed a finite element model capable of predicting the procedure’s effects on individual patients. To validate its reliability and clinical potential, the model was tested using clinical data from two independent ophthalmic clinics.

Congratulations to Dr. Matteo Frigelli on this incredible achievement in developing predictive computational tools for clinical use!

Publications:

Frigelli, Matteo; Ariza Gracia, Miguel Á.; Aydemir, M. Enes; Torres-Netto, Emilio A.; Hafezi, Farhad; Rozema, Jos; Büchler, Philippe; Kling, Sabine (2024). Predicting the Refractive Effects of Customized Corneal Cross-Linking. Investigative Ophthalmology & Visual Science (in revision).

Frigelli, Matteo; Lohmüller, Robert; Ariza Gracia, Miguel Á.; Schlunck, Gunther; Lang, Stefan J.; Torres-Netto, Emilio A.; Hafezi, Farhad; Büchler, Philippe; Kling, Sabine (2024). Integration of mechanical testing, in vivo optical coherence elastography and personalized finite element modeling to predict refractive outcomes of corneal cross-linking. Computers in Biology and Medicine (in revision).

Kling, Sabine; Frigelli, Matteo; Aydemir, M. Enes; Tahsini, Vahoora; Torres-Netto, Emilio A.; Kollros, Léonard; Hafezi, Farhad (2024). Optical coherence tomography quantifies gradient refractive index and mechanical stiffness gradient across the human lens. Communications Medicine 4(162). Springer Nature 10.1038/s43856-024-00578-9

Frigelli, Matteo; Büchler, Philippe and Kling, Sabine (2024). Dynamic evaluation of corneal cross-linking and osmotic diffusion effects using optical coherence elastography. Scientific Reports 14(1), p. 16614. Springer Nature 10.1038/s41598-024-67278-1

Frigelli, Matteo; Büchler, Philippe and Kling, Sabine (2023). Optomechanical assessment of photorefractive corneal cross-linking via optical coherence elastography. Frontiers in Bioengineering and Biotechnology 11, p. 1272097. Frontiers Media 10.3389/fbioe.2023.1272097