PD Dr. Francesco Clavica

Head Urogenital engineering (UGE)

University of Bern, ARTORG Center for Biomedical Engineering Research, Urogenital Engineering

Phone
+41 31 632 7601
Fax
+41 31 632 7576
E-Mail
francesco.clavica@unibe.ch
Postal Address
ARTORG Center for Biomedical Engineering Research
Freiburgstrasse 3
CH-3010 Bern
 
 2020 - December  Habilitation - Venia Docendi, Faculty of Medicine, University of Bern, Switzerland
2019 - present Group head of Urogenital Engineering Group, ARTORG Center, University of Bern, Switzerland 
2018 - present  Senior Reseacher at Center for Artificial muscle (CAM) -  Ecole Polytechnique Fédérale de Lausanne (EPFL)
2018 - present
Senior Researcher at CArdiovascular Engineering Group, ARTORG Center, University of Bern, Switzerland
2011 - 2014 Marie Curie Research fellow at (joint position):
- Department of Urology, Erasmus Medical Center, Rotterdam, The Netherlands    
- Bristol Urological Institute, Southmed hospital, Bristol, United Kingdom      
2007 - 2011 PhD at Brunel Institute for Bioengineering, Brunel University, London, United Kingdom
 2007 Apr-Aug Research Assistant at Neurosurgery Department, Cleveland Clinic, Cleveland, USA
 2001 - 2006 MSc and BSc in Biomedical Engineering, Politecnico di Milano, Milan, Italy
  • Biomedical fluid dynamics
  • Medical devices for urinary system
  • Medical devices for cardiovascular system
  • Microfluidics
  • Wave analysis
  • Electrophysiology
  • Respiratory system

Journal articles

Zheng S, Amado P, Obrist D, Burkhard F, Clavica F. 'An in vitro bladder model with physiological dynamics: Vesicoureteral reflux alters stent encrustation pattern' Frontiers in Bioengineering and Biotechnology, 2022. DOI:  10.3389/fbioe. 2022.1028325

Zheng S., Obrist D., Burkhard F., Clavica F. 'Fluid mechanical performance of ureteral stents: The role of side hole and lumen size' Bioengineering & translational medicine Wiley, 2022. DOI:  10.1002/btm2.10407

Martinez, Thomas ; years, Silje Ekroll ; Walter, Armando ; Chavanne, Jonathan ; Clavica, Francesco ; Ferrari, Lorenzo ; Heinisch, Paul Philipp ; Casoni, Daniela ; Haeberlin, Andreas ; Luedi, Markus M ; Obrist, Dominik ; Carrell, Thierry ; Civet, Yoan ; Perriard, Yves. A novel soft cardiac assist device based on a dielectric elastomer augmented aorta: an in vivo study. Bioengineering & translational medicine Wiley 2022  10.1002/btm2.10396

Thirugnanasambandam M, Frey S, Rösch Y, Mantegazza, Clavica F , Schwartz RS, Cesarovic N, Obrist D. 'Effect of Collateral Flow on Catheter-Based Assessment of Cardiac Microvascular Obstruction' Annals of Biomedical Engineering, 2022. DOI:  10.1007/s10439 -022-02985-2

Zheng S, Amado P, Kiss B, Stangl F, Haeberlin A, Sidler D, Obrist D, Burkhard F, Clavica F. 'Quantitative Evaluation of Encrustations in Double-J Ureteral Stents With Micro-Computed Tomography and Semantic Segmentation' Front. urol. 2:836563, 2022. DOI: 10.3389/fruro.2022.836563

Abou-Hassan A, Barros A, Buchholz N, Carugo D, Clavica F , De Graaf P, De La Cruz J, Kram W, Mergulhao F, L Reis R, Skovorodkin I, Soria F, Vainio S & Zheng S. 'Potential strategies to prevent encrustations on urinary stents and catheters – thinking outside the box: A European Network of Multidisciplinary Research to Improve Urinary Stents (ENIUS) Initiative' Expert Review of Medical Devices 2021, DOI:  10.1080/17434440.2021.1939010

Zheng S, Carugo D, Mosayyebi A, Turney B, Burkhard F, Lange D, Obrist D, Waters S, Clavica F. 'Fluid mechanical modeling of the upper urinary tract' , WIRES Mechanisms of Disease , 2021 . DOI:  10.1002/wsbm.1523

Almanza M, Clavica F , Chavanne J, Moser D, Obrist D, Carrel T, Civet Y, Perriard Y. 'Feasibility of a Dielectric Elastomer Augmented Aorta' Advanced Science , 8(6): 2001974 , 2021. DOI: 10.1002/advs .202001974

Mantegazza A, Ungari M, Clavica F , Obrist D. 'Local versus global blood flow modulation in artificial microvascular networks: effects on red blood cell distribution and partitioning' Frontiers in Physiology , 11 :566273, 2020. DOI: 10.3389/ fphys.2020.566273

Mantegazza A., Clavica F. , Obrist D. 'In vitro investigations of red blood cell phase separation in a complex microchannel network',   Biomicrofluidics , 14:014101 , 2020. DOI: 10.1063/1.5127840

Chakrabarty B, Bijos D, Vahabi B, Clavica F , Kanai AJ, Pickering A, Fry C, Drake MJ 'Modulation of Micromotions Alter Intravesical Pressure in the Rat Bladder' Frontiers in Physiology , 9:1937, 2019. DOI: 10.3389/fphys.2018.01937

Haeberlin A, Schurch K, Niederhauser T, Sweda R Schneider MP Obrist D, Burkhard F, Clavica F 'Cardiac electrophysiology catheters for electrophysiological assessments of the lower urinary tract - an ex vivo feasibility study in living ureters ' Neurourology and Urodynamics 87-96, 2019. DOI: 10.1002/nau.23816

Niederhauser T, Gafner E, Cantieni T, Grämiger M, Haeberlin A, Obrist D, Burkhard F, Clavica F. 'Detection and quantification of overactive bladder activity in patients: Can we make it better and automatic? ' Neurourology and Urodynamics , 1-9, 2018. DOI: 10.1002/nau.23357

van Asselt E, Choudhary M, Clavica F , van Mastrigt R 'Urethane anesthesia in acute lower urinary tract studies in the male rat.' Laboratory Animals : 1-7, 2017. DOI: 10.1177/0023677216657850

Clavica F. , Homsy A., Jeandupeux L., Obrist D., 'Red blood cell phase separation in symmetric and asymmetric microchannel networks: effect of capillary dilation and inflow velocity' Scientific Reports, Nature publishing group , 6:36763, 2016 .DOI : 10.1038/srep36763

Choudhary M., Clavica F. , van Mastrigt Ron, van Asselt E. 'A novel single compartment in vitro model for electrophysiological research using the Perfluorocarbon FC-770', Physiological Research , 20;65(2):341-8, 2016. DOI: 10.33549/physiolres.933099

Choudhary MS, E van Asselt, R van Mastrigt, F Clavica , 'Neurophysiological modeling of bladder afferent activity in the rat overactive bladder model', Journal of Physiological Sciences , 65(4):329-38, 2016. DOI : 10.1007/s12576-015-0370

Clavica F. , Parker K., Khir WA, 'Wave intensity analysis in air-filled flexible vessels', Journal of Biomechanics, 26, 48(4):687-94, 2015. DOI:  10.1016/j.jbiomech.2014.12 .037

Clavica F. , Choudhary MS, van Asselt E., van Mastrigt R., 'Frequency analysis of urinary bladder pre-voiding activity in normal and overactive rat detrusor.' Neurourology and Urodynamics, vol. 34, pp. 794-9, 2015. DOI:  10.1002/nau.22664

Clavica F , Zhao X, ElMahdy M, Drake MJ, Zhang X, Carugo D, 'Beyond the Abstract - A biomimetic artificial model to investigate flow dynamics in the obstructed and stented ureter', UroToday International Journal 2014.

Clavica F. , Zhao X., ElMahdy M., Drake MJ, Zhang X., Carugo D., 'Investigating the flow dynamics in the obstructed and stented ureter by means of a biomimetic artificial model.' PLOS ONE; 9(2):e87433, 2014. DOI:  10.1371/journal.pone.0087433

 

Patents

Clavica F. , Obrist D., Burkhard F., Schneider M., 'Urinary pumping device with an implantable activation arrangement'; European Patent Application EP19/154102.8 priority date: 29.01.2019

Clavica F. , Obrist D., Burkhard F., Schneider M., 'External impedance pump for emptying the bladder'; Swiss Patent Application CH 00096/19priority date: 01/29/2019

Bernard A, Heeb P, Nef C, Obrist D, Clavica F , Frey S, Schwartz R, Hoem J and Bludau O. Microfluidic coronary circulatory model. United States Patent Application 4629.003PRV, 2018 (APPROVED IN US and Europe)

 

Peer-reviewed conference papers

* Corresponding author

Zheng S. , Obrist D., Carugo D., Waters S., Burkhard F., Clavica F. 'An in-vitro investigation in stented ureter using Micro-Particle Image Velocimetry: does stent side-hole diameter matter? 9th World Congress of Biomechanics , Taipei, July 2022

Amado P. , Zheng S., Kiss B., Obrist D., Burkhard F., Clavica F. , 'An in-vitro platform of the urinary tract mimicking physiological/pathological bladder filling and emptying cycles' 9th World Congress of Biomechanics , Taipei, July 2022 

Zheng S. , Amado P., Kiss B., Stangl F., Häberlin A., Obrist D., Burkhard F., Clavica F. 'Quantitative analysis of ureteral stents: encrustation depends on indwelling time and stent region' submitted to 38th World Congress of Endourology and Urotechnology , Hamburg, Germany, 2021

Chavanne J,  Clavica F , Martinez T, Civet Y, Obrist D, Perriard Y ' Energy Analysis of a Cardiac Assist Device based on Dielectric Elastomer Actuator through an Equivalent Electrical Circuit'. In: IEEE/ASME International Conference on Advanced Intelligent Mechatronics (AIM), Delft, the Netherlands, 2021 

Zheng S. , Obrist D., Carugo D., Waters S., Burkhard F., Clavica F. 'The Interplay between fluid mechanics and encrustations on indwelling ureteral stents' 26th Congress of the European Society of Biomechanics , Milan, Italy , July 2021

Bereuter L., Ferrari L., Costantino ML, Civet Y., Perriard Y., Kiss B., Obrist D., Burkhard F., Clavica F. 'In-vitro platform for wave propagation investigations in the lower urinary tract' at 26 th , European Society of Biomechanics, Milan, Italy, July 2021

Chavanne J, Haenni J, Martinez T, Moser D, Walter A, Almanza M, Clavica F , Civet Y, Perriard Y. 'Manufacturing and Tests of a Tubular Multilayer Dielectric Elastomer Actuator for an Impedance Pump' 23rd International Conference on Electrical Machines and Systems (ICEMS), Hamamatsu, Japan, November 2020.

Clavica F. , Zheng S. Carugo, D., Mosayyebi, A., Waters, S., Civet, Y., Perriard, Y., Obrist D., Burkhard F. 'Development of a biologically inspired in-vitro platform for long-term assessment of commercialand innovative ureteral stents' Institution of Mechanical Engineers' conference - Incontinence: the engineer-ing challenge, London, UK, November 2019.

Mosayyebi A., De Grazia A., Clavica F. , Lange D.; Somani B.; Manes C.; Carugo D., 'Does flow dynamics govern deposition of encrustation in ureteral stents?' Institution of Mechanical Engineers' conference - Incontinence: the engineering challenge, London, UK, November 2019.

Clavica F, Roth J, Schneider MP, Civet Y, Burkhard F, Perriard Y, Obrist D 'Impedance pumping as a non-invasive treatment for underactive bladder? An ex-vivo proof-of-concept-study in porcine bladders' Institution of Mechanical Engineers' conference - Incontinence: the engineering challenge, London, UK, November 2019.

Mantegazza A, Clavica F. , Obrist D. 'Microfluidic investigation of red blood cell phase separation in complex microchannel networks' 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS), Basel, Switzerland, October 2019.

Clavica F , Roth J, Schneider MP, Civet Y, Burkhard F, Perriard Y, Obrist D. 'Urine-Contactless Device to Empty Bladders: an Ex-Vivo Proof-of-Concept Study in Porcine Bladders' 49th Annual of Conference of International Continence Society (ICS), Gothenburg, Sweden, September 2019.

Mantegazza A., Clavica F. , Obrist D. 'Tubular pinch effect of red blood cells at low Reynolds number in in vitro models of microvascular bifurcations' 8th World Congress of Biomechanics, Dublin, Ireland, 2018.

Mantegazza A., Clavica F. , Obrist D. 'In vitro measurements of apparent intrinsic viscosity in function of tube hematocrit and red blood cell velocity' Blood flow conference, Paris, France, 2017.

Niederhauser T, Cantieni T, Grämiger M, van Mastrigt R, Burkhard F, Obrist O, Clavica F., 'Towards an automatic detection and quantification of urinary bladder activity in overactive bladder patients' Annual congress of Swiss , Austrian and German Societies of Biomedical Engineering (BMT conference), Basel, Switzerland, 2016.

Clavica F. , A. Homsy, L. Jeandupeux, H. Keppner, D. Obrist "Blood cell dynamics in a simple model of microvascular networks" 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS), Gyeongju, South Korea, 2015.

Grundmann A., Clavica F. , Landolt A., Barrett M., Weber D. Obrist "Measurement of Fluid Pressure in Microchannels" 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS), Gyeongju, South Korea, 2015 .

Zolliker D, Niederhauser T, Grämiger M, van Mastrigt R, Burkhard F, Obrist O, Clavica F , "Frequency analysis of urinary bladder pre-voiding activity in normal and overactive human detrusor: a pilot study ” Proceedings of the 37th Annual International IEEE EMBS Conference, Milan, Italy, 2015.

Carugo D., Zhang X., Drake JM, Clavica F. , "Formation and characteristics of laminar vortices in micro-scale environments within an obstructed and stented ureter: a computational study" 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS) San Antonio, USA, 2014.

Clavica F. , Barrett M., Weiss P., Landolt A, Weber B., Obrist D., "In vivo assessment of hematocrit distribution at bifurcation in cerebral microcirculation" Annual meeting of Swiss Society for Biomed. Engineering, Zurich, Switzerland, 2014.

Choudhary M S, van Asselt E, Clavica F , van Mastrigt R ” Validation of rat overactive bladder model by bladder wall stress estimation”, International Continence Society Conference (ICS), Barcelona, ​​Spain, 2013.

Carugo D, ElMahdy M, Zhao X, Drake MJ, Zhang X, Clavica F , "An Artificial Model for Studying Fluid Dynamics in the Obstructed and Stented Ureter", Proceedings of the 35th Annual International IEEE EMBS Conference, Osaka, Japan, 2013.

Choudhary M S, van Asselt E, van Mastrigt R, Clavica F , "A Novel Single Compartment In Vitro model: Perflurocarbons for Electrophysiological studies of the Rat Urinary Bladder", Proceedings of the 35th Annual International IEEE EMBS Conference, Osaka, Japan, 2013.

Clavica F. , Choudhary MS, van Asselt E., van Mastrigt R., "Can an Algorithm Predict a Voiding Contraction in Unconscious Rats?", Proceedings of the 35th Annual International IEEE EMBS Conference, Osaka, Japan, 2013.

Bijoś D., Drake MJ, Clavica F. , Vahabi B., "Identification of anoctamine (Ano1) calcium activated chloride channels in porcine urinary bladder and characterization of their functional role in the bladder using niflumic acid", International Continence Society Conference ( ICS), Beijing, China, 2012.

Choudhary MS, Clavica F. , van Asselt E., van Mastrigt R., "Frequency analysis of afferent nerve activity in the rat overactive urinary bladder model", Proceedings of the 34th Annual International IEEE EMBS Conference, San Diego, USA, 2012 .

Clavica F. , Alastruey J., Sherwin SJ., Khir AW, "One-dimensional computational model of an asymmetrical human bronchial tree", Physiologic Fluid Mechanics Conference, London (UK) (winner of the best poster prize), 2011 .

Clavica F. , Alastruey J., Sherwin SJ, Khir AW, "One-Dimensional Computational Model of Pulse Wave Propagation in the Human Bronchial Tree", Proceedings of the 32nd Annual International IEEE EMBS Conference, Buenos Aires, Argentina, 2010.

Clavica F. , Alastruey J., Sherwin SJ., Khir AW, "One-dimensional Modeling of Wave Propagation in a Model of Human airways", 17th Congress of the European Society of Biomechanics, Edinburgh, UK, 2010.

Clavica F , Alastruey J, Sherwin SJ, Khir AW, "One-dimensional Modeling of Pulse Wave Propagation in a Model of Human airways", Proceedings of the 31st Annual International IEEE EMBS Conference, Minneapolis, USA, 2009.